原发性肾病综合征的免疫抑制剂治疗

The Treatment of Immunosuppressant in Primary Nephritic Syndrome

免疫抑制剂在原发性肾病综合征(PNS)的治疗中起着非常重要的作用,选择合理的用药方案是PNS治疗取得良好疗效的关键,但目前尚无统一的治疗方案和理想的治疗药物。正确的较长时间使用泼尼松可提高治疗的缓解率及降低复发的危险性;某些难治性PNS可试用甲泼尼松冲击,或加用细胞毒药物,多种新型免疫抑制剂单独或联合使用治疗PNS取得较好疗效,针对导致不同组织损伤的多种免疫反应途径联合使用具有不同免疫抑制效应的多种药物,可能提高PNS的疗效及改善远期预后。

Immunosuppressant plays a very important role in the primary nephrotic syndrome（PNS）.To select a reasonable regimen is the key to get the good curative effect in the PNS treatment.But at present,there is no unified plan and ideal drug for treatment.The correct longer using of prednisone can improve the recurrent rate of the treatment and reduce the risk of relapse.Some intractable PNS can try methylprednisolone,or use cytotoxic drugs.Many new immunosuppressant used alone or combined is getting a good curative effect in the PNS curative effect.According to various ways of immune response which lead to different tissue damage,the combined used of different drugs of immune suppression may be can improve the curative effect and the long-term prognosis of PNS.