复方醋酸钠联合血浆治疗海水浸泡创伤性休克的研究

Hypertonic NaAc and plasma in the treatment of hemorrhagic shock with seawater immersion

目的探讨复方醋酸钠联合血浆对海水浸泡创伤性休克的治疗效果,为早期救治提供实验依据。方法建立海水浸泡创伤性休克大鼠模型,随机分为对照组、复方醋酸钠(HSA)组和复方醋酸钠联合血浆(HSA+P)组,观察各组存活率、平均动脉压、血气、凝血酶原时间(PT)、部分凝血活酶时间(APTT)、D-二聚体等变化。结果对照组大鼠平均动脉压显著降低,并出现酸碱失衡及凝血功能紊乱,HSA组大鼠相关指标有所改善,HSA+P组大鼠的平均动脉压、PH值、HCO32-、PT、APTT、D-二聚体等指标的改善情况显著优于对照组和HSA组大鼠(P<0.05)。结论复方醋酸钠联合血浆能够纠正海水浸泡创伤性休克大鼠的凝血功能障碍、稳定血压以及改善预后,是减少早期死亡的有效治疗手段。

Objective To investigate the effect of hypertonic acetate and plasma on hemorrhagic shock rats immersed in seawater. Methods 30 rats with hemorrhagic shock combined with seawater immersion were randomly divided into 3 groups： control group, hypertonic acetate （HSA）group and hypertonic acetate and plasma （HSA ＋ P） group. The following parameters were measured and recorded： survival rate, mean material blood pressure, protherombin time, partial thromboplastin time, D - dimer and factor II. Results The survival rate of rats in HSA and HSA ＋ P group was significantly longer than that of control group （ P 〈 0.05 ）. The mean material blood pressure and coagulation function was improved and the fibrinolytic activity alleviated in the rats in HSA ＋ P group compared with that in HSA group. Conduslon Together with small volume hypertonic acetate, infusion of plasma can im prove the prognosis, restore coagulation disorders and help managing shock. This treatment may be helpful in preventing early death.