血清Pro-GRP和NSE检测在小细胞肺癌中的意义

The significance of serum Pro-GRP and NSE detection in small cell lung cancer

目的探讨血清胃泌素释放肽前体(Pro-GRP)检测在小细胞肺癌诊断中的价值,并与神经元特异性烯醇酶(NSE)进行比较。方法采用电化学发光法检测68例小细胞肺癌,120例非小细胞肺癌,30例肺部良性疾病和150例健康人血清Pro-GRP和NSE的含量。结果小细胞肺癌患者血清Pro-GRP和NSE水平显著高于非小细胞肺癌、良性疾病组和健康人(P<0.05)。Pro-GRP和NSE对在小细胞肺癌诊断的敏感性分别为80.9%和83.8%,特异性分别为90.2%和58.2%;Pro-GRP和NSE浓度在化疗后均下降;在复发/进展的患者中,Pro-GRP的阳性率显著高于NSE(85%vs50%,P<0.05)。结论血清Pro-GRP检测对小细胞肺癌诊断敏感性和特异性强;还可以反映疗效,监测复发。

Objective To study the diagnostic value of serum progastrin-releasing peptide（Pro-GRP）detection in small cell lung cancer,and to compare with neuron-specific enolase（NSE）detection.Methods Serum Pro-GRP and NSE in 68 small cell lung cancer（SCLC）,120 non-small cell lung cancer（NSCLC）,30 benign pulmonary diseases and 150 healthy cases were detected by electrochemiluminescence method.Results The concentration of Pro-GRP and NSE in patients with SCLC was significantly higher than the patients with NSCLC,benign pulmonary diseases,and healthy persons.The sensitivity of Pro-GRP and NSE detection in SCLC were 80.9%and 83.8% respectively,and specificity were 90.2%and 58.2%respectively.The concentration of Pro-GRP and NSE decreased after chemotherapy.In patients with relapsed or progressed SCLC,the positive rate of Pro-GRP was significantly higher than NSE（85%vs 50%,P〈0.05）.Conclusion Serum Pro-GRP detection is sensitive and specific in the diagnosis of SCLC,which could also reflect therapeutic effect and monitor relapse.