山东省滨州市123例肺结核患者痰结核菌耐药情况分析

Analysis on drug-resistance of tuberculosis in sputum of 123 TB patients in Binzhou city of Shandong province

目的探讨肺结核患者痰结核菌的耐药情况。方法采用痰结核分支杆菌培养并做药物敏感性试验检测。结果肺结核患者耐药率为58.54%;耐异烟肼(INH,H)37.4%、利福平(RFP,R)13.8%、链霉素(SM,S)56.1%、乙胺丁醇(EMB,E)2.4%。至少耐异烟肼和利福平两种药的比例为16.26%。结论肺结核耐药情况严重,尤其是耐多药比例偏高,应引起足够重视。

Objective To investigate the sputum of patients with pulmonary tuberculosis drug resistance in tuberculosis.Methods of sputum Mycobacterium tuberculosis culture and drug sensitivity test done.The outcome of patients with drug-resistant tuberculosis rate of 58.54%;resistant to isoniazid（INH,H）37.4%,rifampicin（RFP,R）13.8%,streptomycin（SM,S）56.1%,ethambutol（EMB,E） 2.4%.At least isoniazid and rifampicin-resistant two drugs for the 16.26 percent ratio.Conclusion serious drug-resistant tuberculosis,especially in acquired drug resistance and the high proportion of multi-drug resistant,which should be sufficient attention.