全肺灌洗术治疗肺泡蛋白沉积症1例并文献复习

A case of pulmonary alveolar proteinosis treated by whole lung lavage and and review of the related litertature

目的探讨肺泡蛋白沉积症的诊断和治疗方法。方法介绍一例肺泡蛋白沉积症的临床资料和诊治经过进行总结,并复习相关文献。结果肺泡蛋白沉积症的发病率近年有上升趋势,临床表现以进展性呼吸困难为主,CT呈毛玻璃样和地图样改变,确诊主要依靠肺泡灌洗液PAS染色和肺组织活检,治疗以全肺灌洗术为主。结论肺泡蛋白沉积症临床表现不典型,疑诊病例行肺活检和PAS染色有助于明确诊断,全肺灌洗术相对支气管灌洗更加确实可行。

Objective To explore the diagnosis and therapy of pulmonary alveolar proteinosis（PAP）.Methods To summary a case of PAP and review the related articles.Results The incidence of PAP was increasing in latest years.The disease was characterized with ongoing dyspnea and typical CT,while the diagnosis was still relied on PAS staining of alveolar lavage and tissue biopsy.At present,the most efficient therapy was whole lung.Results The clinical feature of PAP is untypical,so the suspected case should undergo bronchial lavage staining and lung biopsy.The whole lung lavage is more effective and acceptable than bronchoalveolar lavage.