2Weikert C,Dierkes J,Hoffmann K,et al.Vitamin B plasma levels and the risk of ischemic stroke and transient ischemie attack in a German cohort[J].Stroke,2007,38:2912-2918.
4Hassan A,Hunt BJ,O'sullivan,et al.Homocysteine is a risk factor tor cerebral small vessel disease,acting via endothelial dysfunction[J].Brain,2004,127:212.
5I Kruman,TS Kumaravel,A Lohani,et al.Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease[J].Neurosci,2002,22:1752.
二级参考文献67
1Loehrer F, Angst C, Brunner F, Haefeli W, Fowler B. Evidence for disturbed S-adenosylmethionine: S-adenosylhomocysteine ratio in patients with end-stage renal failure: a cause for disturbed methylation reactions? Nephrol Dial Transplant 1998; 13:656-661.
2Melnyk S, Pogribna M, Pogribny IP, Yi P, James SJ. Measurement of plasma and intracellular S-adenosylmethionine and Sadenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5'-phosphate concentrations. Clin Chem 2000; 46:265-272.
3Caudill MA, Wang JC, Meinyk S, Pogribny IP, Jernigan S, Collins MD, Santos-Guzman J, Swendseid ME, Cogger EA, James SJ.Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J Nutr 2001; 131:2811-2818.
4Lentz SR, Malinow MR, Piegors DJ, Bhopatkar-Teredesai M,Faraci FM, Heistad DD. Consequences of hyperhomocyst(e)inemia on vascular function in atherosclerotic monkeys.Arterioscler Thromb Vasc Biol 1997; 17:2930-2934.
5Charpiot P, Bescond A, Augier T, Chareyre C, Fraterno M,Rolland PH, Garcon D. Hyperhomocysteinemia induces elastolysis in minipig arteries: structural consequences, arterial site specificity and effect of captopril-hydrochlorothiazide.Matrix Biol 1998; 17:559-574.
6Smith TP, Cruz CP, Brown AT, Eidt JF, Moursi MM. Folate supplementation inhibits intimal hyperplasia induced by a highhomocysteine diet in a rat carotid endarterectomy model. J Vasc Surg 2001; 34:474-481.
7Fu WY, Dudman NP, Perry MA, Wang XL. Leukocytes extravasation in acute homocysteinemic rats. Atherosclerosis 2002;161:177-183.
8Dayal S, Arning E, Bottiglieri T, Boger RH, Sigmund CD, Faraci FM, Lentz SR. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke 2004; 35:1957-1962.
9Hofmann MA, Lalla E, LuY, Gleason MR, Wolf BM, Tanji N,Ferran LJ, Jr, Kohl B, Rao V, Kisiel W, Stern DM, Schmidt AM. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest 2001; 107:675-683.
10Watanabe M, Osada J, Aratani Y, Kluckman K, Reddick R,Malinow MR, Maeda N. Mice deficient in cystathionine betasynthase: animal models for mild and severe homocyst(e)inemia.Proc Natl Acad Sci USA 1995; 92:1585-1589.
2Barnett DA, Wilson RS, Gilley DW, et al. Clinical diagnosis of Bins wanger disease. J Neurol Neurosurg Psychiatry, 1990,53:961-965.
3Caplan MD, Lindaren A, Brattstrom L, et al. Binswanger' s disease revisi- ted. Neurology,1995,45 : 626-633.
4Chao CI, Kuo TL, Lee YT: Effects of methionie induced hyperhomocys- teinemia on endothelium-dependent vasodilation and oxidative status in healthy adults. Circulation,2000,101:485-490.
5Grah IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease. JAMA,1997,277: 1775-1781.
