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儿童产超广谱β-内酰胺酶细菌感染耐药性研究

Antimicrobial resistance of extended-spectrum beta-lactamase-producing bacterial infection in children
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摘要 目的比较儿童送检标本分离的产超广谱β-内酰胺酶(Extended-spectrum beta-1actamase,ESBLs)细菌的耐药性,为临床抗ESBLs菌株感染治疗提供参考依据。方法抽取山西省儿童医院2007年1月-2009年4月各类送检标本分离的ESBLs阳性和阴性菌株各100株进行耐药性比较。结果 200株菌株对亚胺培南全部敏感;而对其他11种抗菌药物的耐药性,ESBLs阳性菌株均高于ESBLs阴性菌株(P≤0.001)。其中ESBLs阳性菌株除对头孢哌酮/舒巴坦的耐药率较低(13.00%)外,对其余头孢类抗生素的耐药率均>98%;对庆大霉素和环丙沙星的耐药率分别高达69.07%和59.18%。结论儿童分离的ESBLs阳性菌对碳青霉烯类或加酶抑制剂复合抗菌药物(如头孢哌酮/舒巴坦)较敏感。 Objective To study the antimicrobial resistance of extended spectrum bets-lactamase(ESBLs)-producing bacteria isolated from children, so as to provide reference for treating infections with ESBLs-produeing bacteria. Methods One hundren ESBLs-producing strains and 100 non-ESBLs-producing strains were randomly selected from Children's Hospital of Shanxi Province between January 2007 and April 2009, and their antimicrohial resistance were campared. Results All 200 strains were sensitive to imipenem; the resistance of ESBLs-positive strains to the other 11 kinds of antimicrohial agents were higher than that of ESBLs-negative strains (P〈0. 001). Except resistance to cefoperazone/sulbactam was low (13. 00%), the resistance of ESBLs positive strains to the other cephalosporins were all〉98% ; The resistant rate to gentamycin and ciprofloxacin was 69.07 % and 59.18 respectively. Conclusion ESBLs-producing strains isolated from children are sensitive to earbapenems or antimicrobial compound inhibitors (such as cefoperazone/sulbactam).
机构地区 山西省儿童医院
出处 《中国感染控制杂志》 CAS 2010年第4期267-268,271,共3页 Chinese Journal of Infection Control
基金 山西省科技厅攻关项目(051099-1)
关键词 超广谱Β-内酰胺酶 抗药性 微生物 儿童 大肠埃希菌 肺炎克雷伯菌 extended-spectrum beta-lactamase drug resistance, microbial child Esckerichia coil Klebsiella pneumonia
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  • 1肖庆忠,苏丹虹,江洁华,钟南山.广州地区3500株革兰阴性杆菌TEM和SHV型超广谱β内酰胺酶基因分型研究[J].中华检验医学杂志,2005,28(10):1010-1014. 被引量:19
  • 2张晶,丁继玲,郑丽霞,郝梅,黄晓红.11837例出院病人院内感染调查分析[J].济宁医学院学报,1996,19(1):59-60. 被引量:1
  • 3朱德妹,汪复,张婴元.2005年上海地区细菌耐药性监测[J].中国感染与化疗杂志,2006,6(6):371-376. 被引量:82
  • 4[1]Sambrook J. Fritsch E F, Maniatis T. Molecular cloning A Laboratory Manual[M]. 2nd ed. Cold Spring Harbor Laboratory Press, 1989. 21-52.
  • 5[3]Amyes SGB, Gemmell CG, Antibotic resistance in bacteria[J]. J Med Microbiol, 1992, 36:4.
  • 6魏云霞 冯向春.176例儿科医院内感染调查分析.中国临床医生,1999,27(5):37-37.
  • 7Kliebe C, Nies BA, Meyer JF, et al. Evolution of plasmidcoded resistance to broad-spectrum cephalosporins[J]. Antimicrob Agents Chemother, 1985, 28(2):302-307.
  • 8Pfaller MA, Segreti J. Overview of the epidemiological profile and laboratory detection of extended-spectrum beta-lactamases[J]. Clin Infect Dis, 2006, 42 Suppl 4:S153-163.
  • 9Stobberingh EE, Arends J, Hoogkamp Korstanje JA, et al. Occurrence of extended-spectrum beta lactamases in Dutch hospitals[J]. Infection, 1999,27(6) :348-354.
  • 10Ishikawa K, Hayakawa S, Miyakawa S, et al. Survey of the susceptibility of urinary isolates to antibacterial agents in 2003[J].J Infect Chemother, 2005, 11 ( 1 ) :44-47.

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