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地特胰岛素——一种个体变异性更低的基础胰岛素 被引量：5

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摘要 健康人群机体通过胰岛素分泌的严密调控使血浆葡萄糖浓度保持在正常水平，包括持续低浓度的基础胰岛素分泌和进餐引发的餐时胰岛素分泌。糖尿病胰岛素治疗中的最大挑战是尽可能地模拟正常个体生理模式的内源性胰岛素分泌的特点。基础胰岛素可通过抑制糖原和脂肪分解从而保证空腹及每餐问血糖正常平稳。
作者 周智广
机构地区 中南大学湘雅二医院内分泌科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2010年第7期558-560,共3页 Chinese Journal of Diabetes
关键词 基础胰岛素 地特胰岛素 甘精胰岛素 变异性
分类号 R587.1 [医药卫生—内分泌]
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参考文献22

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同被引文献32

  • 1杨文英.地特胰岛素治疗2型糖尿病的耐受性、安全性和依从性[J].中华糖尿病杂志,2009,1(1). 被引量：16
  • 2陆菊明.地特胰岛素的临床实践:PREDICTIVE研究结果分析[J].中华糖尿病杂志,2010,2(1). 被引量：5
  • 3Selam JL. How to measure glycemic instability? Diabetes Metab, 2000, 26:148-151.
  • 4Heise T, Nosek L, Ronn BB, et al. Lower within-subject variability of insulin detemir in comparison to NPH insulin and in- sulin glargine in people with type 1 diabetes. Diabetes, 2004, 53..1614 1620.
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  • 6Philis-Tsimikas A, Charpentier G, Clauson P, et al. Comparison of once-daily insulin detemir with NPH insulin add to a regimen of antidiabetic drugs in poorly controlled type 2 diabetes. Clin Ther, 2006, 28:1569 1581.
  • 7Hermansen K, Davies W, Derezinski T, et al. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care, 2006, 29:1269-1274.
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  • 10POLLOCK RF, ERNY - ALBRECHT KM, KALSEKAR A, et al. Long- acting insulin analogs: a review of " real - world" effectiveness in patients with type 2 diabetes [ J ]. Curt Diabetes Rev,2011,7( 1 ) :61 -74.

引证文献5

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中国糖尿病杂志
2010年 第7期

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