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关于非编码RNA研究的一些思考 被引量：5

Some reflection on the non-coding RNA research
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摘要 近年来大量的新的转录组实验结果表明基因组中的非编码序列绝大部分是可以表达的,同时越来越多的事实证明转录出来的非编码RNA,从长度为21～24个核苷酸的microRNA到长度为数千核苷酸的Xist,都具有重要的生物学功能。本文主要表达了作者对未来非编码RNA研究方向与重点的一些想法。 The results of large scale transcriptional analyses in recent years suggest that sequences in the noncoding parts of the genome may be expressed in the form of noncoding RNAs. And accumulating evidence suggest that noncoding RNA,from 21-24 nt microRNA in length to the length of knt magnitude Xist,has important biological function. This paper mainly expresses some reflection on the future research direction and focus of the non-coding RNA study.
作者 陈润生
机构地区 中国科学院生物物理学研究所
出处 《生命科学》 CSCD 北大核心 2010年第7期594-597,共4页 Chinese Bulletin of Life Sciences
关键词 生物信息学 非编码RNA 双色网络 bioinformatics noncoding RNA bicolour network
分类号 Q522 [生物学—生物化学]
  • 相关文献

参考文献20

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二级参考文献41

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共引文献21

同被引文献66

  • 1李明振,张铭,明镇寰.Junk DNA的功能诠释[J].生物化学与生物物理进展,2004,31(6):479-481. 被引量：4
  • 2王丽丽,章平.microRNAs及其功能的研究进展[J].细胞生物学杂志,2006,28(5):646-650. 被引量：5
  • 3邹凌云,王正志.基于主成分分析-神经网络的非编码RNA预测[J].生物医学工程研究,2007,26(1):6-9. 被引量：6
  • 4Emily F. Finnegan,Amy E. Pasquinelli.MicroRNA biogenesis: regulating the regulators[J].Critical Reviews in Biochemistry and Molecular Biology.2013(1)
  • 5NobuyoshiKosaka,HaruhisaIguchi.Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis[J].Cancer Science.2010(10)
  • 6Yihui Ma,Shuangni Yu,Wugan Zhao,Zhaohui Lu,Jie Chen.miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2[J].Cancer Letters.2010(2)
  • 7Jian Zhang,Tao Zhang,Xinyu Ti,Jieran Shi,Changgui Wu,Xinling Ren,Hong Yin.Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway[J].Biochemical and Biophysical Research Communications.2010(1)
  • 8Soeren Torge Mees MD,Wolf Arif Mardin MD,Sonja Sielker,Edith Willscher,Norbert Senninger PhD,Christina Schleicher MD,Mario Colombo-Benkmann PhD,Joerg Haier PhD.Involvement of CD40 Targeting miR-224 and miR-486 on the Progression of Pancreatic Ductal Adenocarcinomas[J].Annals of Surgical Oncology.2009(8)
  • 9Christopher A Brosnan,Olivier Voinnet.The long and the short of noncoding RNAs[J].Current Opinion in Cell Biology.2009(3)
  • 10Chris P. Ponting,Peter L. Oliver,Wolf Reik.Evolution and Functions of Long Noncoding RNAs[J].Cell.2009(4)

引证文献5

二级引证文献6

生命科学
2010年 第7期

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