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microRNA调控网络与肿瘤 被引量:3

MicroRNA regulatory network and cancer
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摘要 microRNA(miRNA)是一类长度约为22nt的小分子非编码RNA,对基因表达进行转录后调控。基因调控网络由各种回路,如前馈和反馈回路组成。它通过将外界刺激整合成合适的输出信号,控制细胞从增殖到死亡几乎所有的生命活动。已知基因调控网络的失调与肿瘤的发生发展密切相关。新近的实验证据表明,miRNA广泛参与基因调控网络中的反馈和前馈回路。该文主要介绍miRNA在基因表达调控网络中的作用及其与肿瘤发生发展的关系。 MicroRNAs (miRNAs) are a class of short (~22 nt),regulatory non-coding RNAs that inhibit the expression of protein-coding genes through binding to the 3'-untranslated region (3'UTR) of target mRNAs. Gene regulatory networks,which are made up of basic subcircuits,such as feedback and feedforward loops,control a wide range of biological processes,including development,cell differentiation,proliferation and apoptosis. Deregulation of gene regulatory network is highly associated with tumorigenesis. Emerging evidences suggest that miRNAs act as critical motifs of feedback and feedforward loops. This review summarizes the recent advance in the research field of miRNA regulatory network and its association with tumorigenesis.
出处 《生命科学》 CSCD 北大核心 2010年第7期634-640,共7页 Chinese Bulletin of Life Sciences
基金 国家重点基础研究发展计划("973"项目)(2005CB724600)
关键词 miRNA调控网络 反馈回路 前馈回路 肿瘤 miRNA gene regulatory network feedback loop feedforward loop cancer
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同被引文献44

  • 1高杰,杨彤涛,裘秀春,范清宇,马保安.microRNA和干细胞的研究进展[J].中国修复重建外科杂志,2007,21(9):1007-1010. 被引量:3
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