尿微量蛋白联合尿酶检测在酒依赖早期肾损害诊断中的意义

Diagnosis of early renal damage in alcohol addicts with urinary microproteins and NAG

目的:了解尿微量蛋白联合尿酶检测在酒依赖早期肾损害诊断中的意义。方法:收集30例正常对照组和22例酒依赖者测定尿中微量白蛋白(mALB)、转铁蛋白(TRF)、视黄醇结合蛋白(RBP)和N-乙酰-β-D-氨基葡萄糖苷酶(NAG),以及血、尿肌酐和血尿素、r-谷氨酰转移酶(GGT)水平。结果:正常对照组尿mALB/Cr(2.81±1.65)mg/mmol,TRF/Cr(0.17±0.14)mg/mmol,RBP/Cr(18.32±5.87)μg/mmol,NAG/Cr(1.42±0.65)U/mmol;酒依赖组尿mALB/Cr(15.33±9.54)mg/mmol,TRF/Cr(1.92±1.09)mg/mmol,RBP/Cr(355.12±265.32)μg/mmol,NAG/C(r9.53±5.22)U/mmol,与正常对照组比较,差异显著(P<0.01)。GGT与尿微量蛋白系列和NAG无相关关系。结论:尿微量蛋白联合尿酶检测能敏感地反映酒依赖者早期肾功能受损的情况,且早于传统生化指标和常规尿蛋白的测定。

Objective： To detect the effect of urinary microproteins and NAG in early stage renal impairment of alcohol addicts. Methods： To detect the urinary N-acetyl-beta-D- glucosaminidase （NAG）, microalbumin （mALB）, retinal binding protein （RBP） and urinary transferrin （TRF） of alcohol addicts group （22 cases） and normal control group （30 cases）. Moreover, glutamyltransferase（GGT）, urea and creatinine（Cr） in serum or urine are detected. Results： In normal controls, the levels of urinary mALB/Cr, TRF/Cr, RBP/Cr and NAG/Cr were （2.81 ± 1.65）mg/mmol, （0.17± 0.14）mg/mmol, （18.32± 5.87）μg/mmol, NAG/Cr （1.42± 0.65）U/mmol respectively; The levels of urinary NAG/Cr, mALB/Cr, TRF/Cr and RBP/Cr in alcohol patients were significantly higher than in control group （P〈0. 01）. GGT was not correlated with microproteins and NAG. Conclusion： Urinary microproteins and NAG are an important index to prognosticate the early stage renal impairment of alcohol addicts.