摘要
目的:了解具有刺激性化妆品的类型分布特点,比较皮肤和眼刺激性试验的敏感性,并分析这两项试验结果的相关性。方法:应用动物试验对140份化妆品样品的皮肤和眼刺激性进行检验,比较和分析试验结果。结果:在140份样品中,对皮肤具有轻刺激性和中刺激性的样品分别占10.7%和5.7%;对眼有轻刺激性、刺激性和腐蚀性的样品分别占11.4%、4.3%和2.9%。对皮肤和眼刺激性最强的化妆品类型是洗发类,其次是沐浴类,再次是护发类、面膜类和洗面类,护肤类刺激性最弱。眼刺激性试验比皮肤刺激性试验敏感性高(Z=-6.67,P<0.01),两种试验结果之间存在较弱的正相关性(r=0.414)。结论:洗发类是对皮肤和眼具有较强刺激性的化妆品类型,一般眼刺激性试验比皮肤刺激性试验敏感性高,两项试验的结果之间存在较弱的正相关性。
Objective:To know the type distributing characteristic of irritating cosmetics,and to compare the sensitivity of dermal irritation test with that of eye irritation test,and to determine whether the correlation exist between the results of these two tests.Methods:Dermal irritation and eye irritation of 140 cosmetics were tested in animals,and the results of tests were comparatively analyzed.Results:Among 140 samples,the cosmetics which caused slight and moderate skin irritation accounted for 10.7% and 5.7% respectively,those caused slight irritation,irritation and corrosiveness to eyes accounted for 11.4%,4.3% and 2.9%,respectively.Shampoo gathered most samples that could cause strong skin and eye irritation.The sensitivity of eye irritation test was higher than that of dermal irritation test(Z=-6.67,P0.01),and there was a positive correlation between the results of these two tests(r= 0.414).Conclusion:Shampoo was relatively strong irritating cosmetic to skin and eye.The sensitivity of eye irritation test was higher than that of dermal irritation test generally,and there was weak positive correlation between the results of these two tests.
出处
《中国卫生检验杂志》
CAS
2010年第7期1701-1702,共2页
Chinese Journal of Health Laboratory Technology