甘肃省1010例唇腭裂患者临床资料分析

Clincial Analysis of 1 010 Patients with Cleft Lip and/or Palate in Gansu Province

目的了解甘肃省先天性唇腭裂的患病状况与特点,分析与唇腭裂发生有关的影响因素,为该地区唇腭裂的病因探讨及预防提供依据。方法对2000年1月至2009年3月住院的1010例先天性唇腭裂患者进行回顾性统计分析。结果本组病例中,唇裂伴腭裂占61.39%,腭裂占16.63%,唇裂占21.98%;男性多于女性(男:女为1.89:1),但不完全腭裂,女性多于男性(女:男为1:0.77);有遗传史者64例,占总例数的6.34%;唇腭裂患者母亲妊娠前3个月接触危险因素者356例(35.25%);患者母亲生育年龄20岁以下者占总例数的20%。结论唇腭裂各类型中,唇裂伴腭裂最常见,男性发病多于女性。先天性唇腭裂病因可能与孕早期感染、重度呕吐、生育年龄过小有关。

Objective To investigate the prevalence and characteristics of cleft lip and/or palate in Gansu province,analyze the influencing factors of cleft lip and/or palate,and thus provide evidence for the etiology and prevention of cleft lip and/or palate.Methods The clinical records of 1 010 patients with congenital cleft lip and/or palate were retrospectively analyzed.Results Among 1 010 patients,620（61.39%）had cleft lip,168（16.38%）had cleft palate,and 222（21.98%）had cleft lip.The male/female ratio was 1.89：1 in all the patients,but in patients with incomplete cleft,palate the male/female ratio was 0.77：1.Of all the patients,64（6.34%）had definitive family history;356 mothers（35.25%）were exposed to risk factors in the first trimester of pregnancy;and 20% of the mothers were younger than 20 years.Conclusion Cleft lip and palate is the most common type.The incidence of cleft lip and/or palate is higher in male than in female.The congenital cleft lip and/or palate may be related to maternal infection and severe vomiting during early pregnancy and young childbearing age.