广州地区医院红细胞悬液输血不良反应的调查

Adverse reactions following RBC suspension transfusion： a Guangzhou survey

目的：对广州地区医院采用红细胞悬液输血不良反应进行回顾性分析。方法：抽样调查广州3家三级甲等医院2005—2008年期间用输全血不良反应发生率；去除白细胞与非去除白细胞的输血不良反应发生率。（不良反应发生率=发生不良反应的例数／红细胞悬液的用量×100％）。结果：三家医院输全血的不良反应总发生率在0．08％至0．48％之间，去除白细胞后的输血不良反应发生率明显减少，与非去除白细胞的输血不良反应发生率差异有显著性（P〈0．05）。结论：广州地区医院采用红细胞悬液的输血不良反应发生率各个医院有差异，去除白细胞输血可以明显降低输血不良反应发生率，对大量输血或反复输血的病人有重要意义。

Objective：To review the adverse reactions following RBC suspension transfusion in Guangzhou area. Methods： A sampling survey was conducted in three tertiary grade A hospitals in Guangzhou, to investigate the rates of adverse reactions following whole-blood transfusion, leucocyte-free and non leucocyte-free blood transfusion between 2005 and 2008. The rate of adverse reaction was calculated as percentage number of cases over use of RBC suspension. Results： In the three hospitals, the rate of adverse reaction varies from 0.08% to 0.48% for whole-blood transfusion. Incidence of adverse reactions was greatly reduced with leucocyte-free blood transfusion, compared significantly with non leucocyte-free blood transfusion （ P 〈 0. 05 ）. Conclusion ： While variation may exist in rate of adverse reaction following RBC suspension transfusion among Guangzhou hospitals, a significant reduction in adverse reactions was seen with leucocyte-free blood transfusion, which can be important for patients in need of massive or repeated transfusion.