大光斑低剂量Q-开关激光治疗黄褐斑疗效

Clinical efficacy of Q-switched, large-spot low-dose laser for treatment of melasma

目的：初步分析Q-开关激光治疗面部黄褐斑新方法的临床效果和安全性。方法：应用Medlite Q-开关激光，波长1064nm，6mm光斑，1～4J／cm^2能量治疗本院40例黄褐斑患者，观察临床疗效及不良反应。结果：40例患者随机分成4个治疗组，分别接受能量密度为1、2、3和4J／cm^2，波长为1064nm，光斑直径为6mm，每10天治疗1次，连续6次的治疗，有4例患者黄褐斑基本完全消退，15例明显消退，13例有效，8例改善不明显，仅l例患者治疗6次后出现色素沉着，黄褐斑加深，未见色素减退和瘢痕。结论：大光斑低剂量Q-开关激光治疗黄褐斑是安全、有效的，不良反应用少，更容易为患者所接受。

Objective：To analyze the clinical efficacy and safety of Q-switched, large-spot low-dose laser in the treatment of melasma. Methods ： Forty patients with melasma in our hospital underwent Medlite Q-switched laser therapy （1064 nm wavelength, 6mm light spot and 1 -4J/cm^2 energy density）. Clinical efficacy and adverse reactions were observed. Result ：40 melasma patients were randomly divided into 4 groups, according to energy density respectively of 1 J/cm^2, 2 J/cm^2 , 3 J/cm^2 and 4 J/cm^2 , with wavelength at 1064 nm and 6mm light spot in diameter. The treatment was performed once every ten days, and for 6 cycles in total. Four patients were cured, 15 reported significant resolution, 13 reported effective and 8 showed no response. Hyperpigmentation and worsened melasma was seen only in 1 case after treatment for 6 cycles. Neither hypopigmentation nor superficial scar was noted in all cases. Conclusion： Q-switched large-spot low-dose laser may be an acceptable treatment due to its efficacy and safety in treatment of melasma with few adverse reactions.