银胡感冒海绵剂解热、抗炎、镇痛作用的实验研究

Experimental Study of Yinhu Ganmao Spongia on Antipyretic,Anti-inflammation and Analgesia

目的:研究银胡感冒海绵剂在解热、镇痛、抗炎等方面的作用,为临床用药提供实验依据。方法:采用2,4-二硝基苯酚致大鼠发热法观察银胡感冒海绵剂的解热作用,小鼠耳肿胀法、大鼠足跖肿胀法观察银胡感冒海绵剂的抗炎作用,小鼠扭体法、小鼠热板法、观察银胡感冒海绵剂的镇痛作用。结果:银胡感冒海绵剂对2,4-二硝基苯酚所致大鼠的发热反应有明显的解热作用;对巴豆油所致小鼠耳壳肿胀和对角叉菜胶所致大鼠足跖肿胀均有显著的抑制作用;能显著抑制醋酸所致的小鼠扭体反应次数并能显著提高小鼠热板痛阈值。结论:银胡感冒海绵剂具有显著的解热、抗炎和镇痛作用。

Objective： To study the pharmacodynamic actions of yinhu ganmao spongia（YHGMS） on anti-cold effects about anti- pyretic, anti-inflamatory and analgesic. Method： Antipyretic action was evaluated with rat pyrogeutic test induced by 2,4-dinitrophenol, analgesia action was investigated with hot plate test and acetic acid writhing test in mice, anti-inflammation action was observed by croton oil-induced tumefaction of ear in mice and paw edema tests in rats induced by carrageenin. Result ： YHGMS could obvious relieved fever caused by 2,4-dinitrophenoan; could inhibited ear edema in mice, paw edema in rats and writhing, could remarkably increased the tolerant value. Conclusion： It is suggested that YHGMS has evident effects of antlpyretic, anti-inflammation, analgesia.