药膳联合生活方式干预对糖调节受损患者的影响

Effect of combining traditional Chinese medicine diet with lifestyle interference on patients with impaired glucose regulation

目的探讨中药膳食联合生活方式（糖尿病知识教育、运动、饮食、减肥等）干预对糖调节受损（IGR）患者的作用效果。方法将社区200例IGR患者随机分为三组，空白组（n=67），予一般糖尿病教育，对照组（n=67）予生活方式指导，干预组（n=66）予生活方式指导联合中药膳食干预。18个月后比较三组IGR患者转归情况及空腹血糖（FBG）、餐后2h血糖（2hPG）及体重指数（BMI）的变化。结果空白组、对照组、干预组三组IGR患者逆转为正常血糖分别为5．97％，29．85％，59．09％；稳定在IGR阶段者分别为79．10％，64．18％，37．88％；发展为糖尿病者分别为14．93％，5．97％，3．03％；对照组、干预组与空白组比较，干预组与对照组比较差异均有统计学意义（P〈0．01）。对照组、干预组患者的FBG,2hPG及BMI与空白组比较差异均有统计学意义（P〈0．01）。结论对IGR患者，在生活方式指导的同时进行中药膳食干预，可进一步降低FBG及2hPG，并改善IGR患者的临床转归。

Objective To investigate effects of combining Traditional Chinese Medicine （TCM） diet with lifestyle interference including disease related knowledge education, movement guidance, diet management and lose weight guidance on the patients with impaired glucose regulation （IGR）. Methods A total of 200 cases of community IGR patients were divided into three groups randomly：67 cases in blank group , 67 cases in comparison group and 66 cases in study group. The comparison group was performed lifestyle guidance while the study group was conducted TCM diet combination with lifestyle interference. Clinical outcomes containing FBG, 2h .PG and BMI were compared at 18 month later among three groups. Results After 18 months, in the three groups（ blank groups, the comparison group and the study group）5.97%, 29.85% and 59.09% patients reverted to normal glucose tolerance, 79. 10%, 64. 18% and 37.88% patients remained IGR and 14.93%, 5.97% and 3.03% patients progressed into the diabetes mellitus. FBG, 2h PG and BMI were significantly different when the comparison group compared with the study group and the blank group compared with the study group or the comparison group. Conclusions Combining TCM diet with lifestyle interference can lower the FBG and 2h PG and improve the clinical outcome for patients with IGR.