5年嗜麦芽寡养单胞菌的临床分布及耐药性变迁

Distribution and Drug Resistance Tendency of Stenotrophomonas maltophilia During Recent Five Years

目的了解5年临床分离的嗜麦芽寡养单胞菌感染分布及耐药性变迁情况。方法回顾性分析2004年1月-2008年12月临床标本中分离的嗜麦芽寡养单胞菌352株,了解其临床感染特点及耐药率的变化。结果嗜麦芽寡养单胞菌临床分布以ICU最多(49.5%),分离标本以痰液最高(82.4%),其对12种抗菌药物耐药率总体呈上升趋势;对磺胺甲噁唑/甲氧苄啶耐药率最低(18.8%～23.9%),而对亚胺培南的耐药率最高为100.0%。结论嗜麦芽寡养单胞菌对多种抗菌药物耐药,治疗应根据体外药敏结果合理使用抗菌药物。

OBJECTIVE To study the distribution and drug resistance of Stenotrophomonas maltophilia in our hospital during recent five years.METHODS Totally 352 strains of S.maltophilia isolated from patients with infection from Jan 2004 to Dec 2008 were collected and drug susceptibility tests were performed.RESULTS Concerning the ward distribution,ICU had the highest rate of 49.5%.In the five years,there was a highest isolation rate of 82.4% in specimens from sputum.S.maltophilia had various drug resistances to 12 kinds of antibiotics,and there was an increasing tendency of resistance rate.The drug susceptibility tests showed that SXT had the lowest resistance rate（18.8-23.9%） and imipenem had the highest（100.0%）.CONCLUSIONS S.maltophilia is resistant to many kinds of antibiotics,so antibiotics must be chosen by drug susceptibility tests in vitro.