脑卒中患者医院获得性肺炎的病原学及耐药性分析

Pathogens and Drug Resistance Analysis in Stroke Patients with Hospital-acquired Pneumonia

目的探讨脑卒中患者并发医院获得性肺炎(HAP)的病原学及病原菌对抗菌药物的耐药性。方法对2006年12月-2008年12月,医院收治的84例脑卒中合并HAP的患者资料进行回顾分析。结果共分离出病原菌158株,其中革兰阴性菌占56.96%,革兰阳性菌占29.74%,真菌占13.29%,致病菌对常用抗菌药物都不同程度地产生了耐药性。结论主要致病菌为革兰阴性杆菌,其次为革兰阳性菌,真菌感染率较高,多种菌群感染、超广谱β-内酰胺酶产生及高耐药率,为导致死亡重要原因。

OBJECTIVE To discuss the etiology and bacterial resistance to antibiotics in patients with stroke,complicated with hospital-acquired pneumonia.METHODS The patients′ documents who were admitted in our hospital from Dec 2006 to Dec 2008 were retrospectively analyzed.RESULTS A total of 158 strains isolated,of which Gram-negative bacteria accounted for 56.96%,Gram-positive for 29.74%,and fungi accounted for 13.29%.They were with varying degrees of resistance to commonly used antibiotics.CONCLUSIONS The main pathogens are Gram-negative bacilli,followed by Gram-positives,and the fungal infection rate higher.The infection with multiple bacteria,production of extended-spectrum β-lactamases and high-resistance drug rate are the main causes to death.