新生儿脐炎病原菌分布及耐药性分析

Neonatal Omphalitis:Pathogen Distribution and Drug Resistance Analysis

目的调查新生儿脐炎病原菌分布及药物敏感状况,为临床医师合理选用抗菌药物提供依据。方法对105例新生儿脐炎患儿作脐分泌物常规细菌培养鉴定,用K-B法测定病原菌耐药性。结果共分离出病原菌73株,其中金黄色葡萄球菌25株,占34.24%,凝固酶阴性葡萄球菌17株,占23.29%,大肠埃希菌10株,占13.70%,奇异变形菌8株,占10.96%,肺炎克雷伯菌7株,占9.59%,其他6株,占8.22%;金黄色葡萄球菌对苯唑西林、利福平、万古霉素、左氧氟沙星的耐药率分别为8.00%、0、0、0;大肠埃希菌对亚胺培南、头孢吡肟、左氧氟沙星、哌拉西林/他唑巴坦、阿米卡星的耐药率均为0。结论分析新生儿脐炎的病原菌分布及药物敏感状况,可以指导临床医师合理使用抗菌药物。

OBJECTIVE To investigate the distribution and drug resistance of bacteria in omphalitis for clinicians to provide a reasonable basis for selection of antimicrobial agents.METHODS From 105 cases of children with omphalitis,their neonatal umbilical secretions were collected for bacterial culturing,conventionally identifing and determining of pathogenic bacteria by K-B method.RESULTS A total of 73 pathogens isolated,including Staphylococcus aureus（25,34.24%）,coagulase-negative staphylococci（17,23.29%）,Escherichia coli（10,13.70%）,Proteus mirabilis（8,10.96%）,Klebsiella pneumoniae（7,9.59%）,and others（6,8.22%）.The resistance rates of S.aureus to oxacillin,rifampicin,vancomycin,and levofloxacin were 8.00%,0,0,and 0.That of E.coli to imipenem,cefepime,levofloxacin,piperacillin/tazobactam,and amikacin rates were all 0.CONCLUSIONS The distribution of pathogens in neonatal omphalitis and drug sensitivity status are analyzed and the clinicians can guide the rational use of antimicrobial agents.