呼吸科病房真菌性肠炎感染分析

Fungal Enteritis in Respiratory Ward:A Clinical Study

目的探讨真菌性肠炎在呼吸科病房的发病相关因素、临床表现及治疗,提高对该病的认识,并制定治疗和预防方案。方法对7年来呼吸科住院患者发生真菌性肠炎的年龄、基础疾病、危险因素、诊断与治疗及预后进行回顾性调查与统计学分析。结果 5800例患者中共发生真菌性肠炎12例,在呼吸科住院患者中发病率为0.2%,均患有较严重的基础疾病;免疫力下降,较长时间使用广谱抗菌药及接受大剂量肾上腺皮质激素治疗以及化疗等因素是主要诱因,均存有菌群失调,部分患者愈后极差,12例中有3例死亡,病死率为16.6%。结论防治真菌性肠炎应采取综合性措施,包括合理使用抗菌药和肾上腺皮质激素,防治菌群失调,缩短住院时间等,对该病应早期诊断与治疗。

OBJECTIVE To approach the clinical correlation factors and morbidity of fungal enteritis with inpatients in the respiratory ward,clinical manifestation,diagnosis treatment and prognosis.To enhance the understanding of this disease and to institute the plan of prevention and treatment.METHODS The age,underlying diseases,risk factors,diagnosis,treatment and prognosis of fungal enteritis in the 5800 inpatients were reviewed retrospectively and analyzed statistically.RESULTS There were 12 cases suffered from fungal enteritis,the morbidity was 0.2%.All of fungal enteritis had several underlying diseases and risk factors,hypoimmunity,using broad-spectrum antibacterials for a long time,receiving large dosage glucocorticoid or other chemotherapy.The fungal enteritis in all of the patients with dysbacteriosis belonged to deep fungal infection,parts of these cases had poor prognosis,3 cases were dead among the 12 patients,the mortality was 16.6%.CONCLUSION The comprehensive measures should be adopted in prevention and treatment of fungal enteritis,which include the rational application of antibiotics and adrenocortical steroid,the prevention and treatment of dysbacteriosis,shortening the time of stay in hospital,early diagnosis and treatment,rational using antifungals and others.