甲醇钠催化的α-羟基异丁酰胺与甲酸甲酯的交换反应

The Exchange Reaction of α-Hydroxyisobutyric Acid Amide and Methyl Formate Catalyzed by Sodium Methoxide

确定了以甲醇钠为催化剂的α-羟基异丁酰胺与甲酸甲酯交换反应生成α-羟基异丁酸甲酯的最佳操作条件，α-羟基异丁酸甲酯的产率可达８２．２％，选择性可达９９．３％。

The optimum exchange reaction conditions of α-hydroxyisobutyric acid amide with methylformate catalyzed by sodium methoxide to form methyl α-hydroxyisobutyrate were determined. The yieldof methyl α-hydroxyisobutyrate was 82. 2 % with the selectivity of 99. 3 %.