凋亡抑制蛋白Livin在宫颈癌及宫颈上皮内瘤变表达

Expression of Inhibitor of Apoptosis Protein,Livin in Cervical Carcinoma and Cervical Intraepithelia Neoplasia

[目的]探讨凋亡抑制蛋白Livin在宫颈上皮内瘤变(CIN)和宫颈癌中的表达及意义。[方法]采用免疫组织化学SP法检测81例宫颈癌、74例CIN和20例正常宫颈组织中Livin的表达情况。[结果]Livin在正常宫颈组织中不表达,在CIN和宫颈癌中表达上调,阳性率分别为31.08%(23/74)和67.90%(55/81)。Livin在CINⅢ组织中的阳性率高于CINⅠ～Ⅱ。Livin表达与肿瘤临床分期、分化程度及淋巴结转移有关(P<0.05),而与病理类型、肿块生长类型无相关性(P>0.05)。[结论]Livin过表达可能与CIN和宫颈癌的发生发展有关,提示肿瘤的恶性程度及不良预后。

[Purpose] To investigate the expression and significance of Livin in CIN and cervical carcinoma. [Methods] The expressions of Livin in 81 cases with cervical carcinoma,74 cases with CIN and 20 cases with normal cervix were detected by SP immunohistochemistry. [Results] Negative expression of Livin in normal cervix tissue,overexpression in CIN and in cervical carcinoma tissue were found,with positive rates 0,31.08%（23/74） and 67.90%（55/81）,respectively. The positive rate in CINⅢ was higher than that in CINⅠ～Ⅱ.The expression of Livin in cervical carcinoma was related to clinical stages,degree of differentiation and lymph node metastasis （P 0.05）,and it was not related to pathological type and tumor growth type （P0.05）. [Conclusion] Over expression of Livin might play an important role in carcinogenesis of CIN and cervical carcinoma,and indicate poor prognosis.