他汀类药物在急性心肌梗死患者无复流现象中脑钠肽表达的影响

Effect of administration of statin on the level of BNP in the no-reflow phenomenon in patients with acute myocardial infarction

目的:通过研究阿托伐他汀对急性心肌梗死(AMI)患者无复流现象中脑钠肽的影响,探讨阿托伐他汀在无复流的作用。方法:根据造影结果将98例行急诊冠状动脉介入治疗的AMI患者分为无复流组和血流正常组,应用酶联免疫吸附法检测患者入院时的血浆脑利钠肽(BNP)、高敏C反应蛋白(hs-CRP)。结果:与血流正常组相比,AMI无复流组患者BNP、CRP显著增高(P<0.05),左室射血分数显著减低,无复流组患者术前他汀类药物使用比例显著减少(P<0.05)。结论:BNP、CRP可能是冠状动脉无复流现象发生的预测因素之一,他汀类干预可以显著减少无复流现象的发生。

Objective：Abstract Objectives：To study the effects of statin on BNP in the no-reflow in patients with AMI,and therefore,provide new theory for the immunoregulation mechanism of statin in the no-reflow of AMI.Method：We prospectively studied 98 patients underwent PCI in the acute myocardial infarction,who were designated to no-reflow group （16 cases） and reflow group （82 cases） according to the angiographic results.BNP、hs-CRP level in the peripheral blood were measured on admission by ELISA.Result：The level of BNP and hs-CRP in the no-reflow group were significantly higher than those in reflow group,wheres the LVEF was converse （P〈0.05）,and the ration of statin therapy was statistical difference between the no-reflow group and reflow group （P〈0.05）.Conclusion：Angiographic no-reflow phenomenon after PCI for AMI may be predicted by levels of BNP and hs-CRP on admission.Statin-guided approach may be useful in preventing patients from suffering from the no-reflow detriment.