氢氯噻嗪固体分散体的制备及其溶出溶解性

Studies on preparation and dissolution of hydrochlorothiazide solid dispersions

目的:采用固体分散技术,提高氢氯噻嗪的体外溶解性能。方法:分别以PEG6000和PVPK30为载体,制备氢氯噻嗪固体分散体。采用紫外分光光度法进行含量测定,差示热分析法鉴别药物在载体中的存在状态,并进行溶解度、体外溶出速率实验。结果:2种载体的固体分散体均能增加药物的溶解度和溶出速率,氢氯噻嗪在载体中以高度分散状态存在。结论:以PVPK30为载体制备的氢氯噻嗪固体分散体体外溶解度和溶出速率明显提高。

OBJECTIVE The solid dispersion method was used to increase the dissolution of hydrochlorothiazide. METHODS Hydrochlorothiazide solid dispersions were prepared respectively with PEG6000 and PVPK30. UV spectrophotometry was used to determine hydrochlorothiazide content. Differential thermal analysis was used to determine the status of hydrochlorothiazide in solid dispersion. The solubility and dissolution rate in vitro were studied. RFSULTS The solubility and dissolution rate of all hydrochlorothiazide solid dispersion were increased. Hydrochlorothiazide were completely dispersed in carrier materials. CONCLUSION The solid dispersion prepared with PVPK30 can increase the solubility and dissolution rate.