mTOR信号通路的生物学功能

The progress of study on the biological function of mTOR pathway

哺乳动物的雷帕霉素靶(mammalian target of rapamycin,mTOR)是一种非典型丝氨酸/苏氨酸蛋白激酶,可整合细胞外信号,磷酸化下游靶蛋白核糖体p70S6激酶,如S6K1及4E-BP1,影响基因转录与蛋白质翻译,从而参与调控细胞生长、增殖等过程。mTOR的生物学功能的多样性,使其成为当今生物学研究的焦点之一。mTOR与蛋白质合成、免疫、细胞运动及代谢、细胞凋亡及自噬等均有联系。

Mammalian target of rapamycin（mTOR） is an atypical Ser/Thr protein kinase,which can integrate extracellular signals,phosphorylate its down-stream p70S6 kinases such as S6K1 and 4EBP1,to play roles in gene transcription and protein translation.Thus it can modulate the processes of cell growth and proliferation.mTOR is becoming a research focus due to its various biological functions associated with protein synthesis,immunity,metabolism and movement,apoptosis and autophagy and so on.