摘要
目的:研究眩晕定颗粒的吸湿性,确定眩晕定颗粒生产过程中合理的湿度条件及暴露时间。方法:通过测定眩晕定颗粒的吸湿速度及平衡吸湿量,建立其动力学模型,提取吸湿速度参数并比较大小。结果:眩晕定颗粒在不同湿度下的吸湿动力学符合房室模型,吸湿量达到6%对应的相对湿度为56.11%,在此湿度下包装前最久可摆放10.15h。结论:眩晕定颗粒生产中应控制环境湿度在56%以下,分装时暴露时间不可超过10.15h。
OBJECTIVE: To study the hygroscopicity of Xuanyunding granule, and to determine reasonable conditions of humidity and exposure time in the production process. METHODS: Dynamics model was established by determining hygroscopic rate and balance moisture absorption volume of Xuanyunding granule. Hydroscopicity rates were determined and compared. RESULTS: Hygroscopicity dynamic equations of Xuanyunding granule at different humidity condition was in line with the compartment model. When absorption capacity reached 6%, relative humidity was 56.11%. Under above condtion, Xuanyunding granule could be stored for 10.15 h at most before packaging. CONCLUSION: In the production process of Xuanyunding granule, humidity should be below 56%, exposure time must be not more than 10.15 hours in packaging process.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第31期2902-2904,共3页
China Pharmacy
基金
湖南省教育厅科学研究项目(01C235)
湖南省卫生厅科研基金课题(C2005-045)
关键词
眩晕定颗粒
吸湿百分率
房室模型
平衡吸湿量
相对湿度
Xuanyunding granule
Moisture absorption percentage
Compartment model
Balance moisture absorption volume
Relative humidity