汉、维吾尔族女性乳腺癌影响因素病例对照研究

Related factors of breast cancer for Han and Uygur nationality in Xinjiang area:a case-control study

目的探讨新疆维吾尔自治区汉族、维吾尔族妇女乳腺癌发病的影响因素。方法于2008年6月-2009年10月对新疆医科大学附属肿瘤医院病理确诊的433例汉族和103例维吾尔族乳腺癌患者进行1∶1病例对照研究,采用单因素和多因素条件Logistic回归进行统计分析。结果汉族和维吾尔族妇女乳腺癌发病共同危险因素为绝经年龄晚、肿瘤家庭史、遭遇重大挫折,其中腌渍食物摄入次数多为汉族妇女乳腺癌单独的危险因素(OR=2.729,95%CI=1.762～4.228),肉类摄入次数多(OR=2.744,95%CI=1.784～4.221)是维吾尔族妇女乳腺癌单独的危险因素;月经规律(OR=0.475,95%CI=0.252～0.893)、蔬菜摄入次数多(OR=0.498,95%CI=0.348～0.712)为汉族妇女乳腺癌保护因素;初潮年龄晚(OR=0.676,95%CI=0.536～0.812),母乳喂养持续时间长(OR=0.496,95%CI=0.269～0.618),活产次数多(OR=0.306,95%CI=0.097～0.965)为维吾尔族妇女乳腺癌保护因素。结论新疆汉族、维吾尔族女性乳腺癌发病影响因素存在差异。

Objective To explore related factors of female breast cancer for Han and Uygur nationality in Xinjiang area.Methods A 1∶1 matched case-control study was conducted in 433 Han and 103 Uygur female breast cancer cases with hitopathological diagnosis and 536 control women receiving medical examination using conditional logistic regression analysis.Results The common risk factors of Han and Uygur female breast cancer included late menopause,family history of cancer,and psychological irritation.The unique risk factor for breast cancer in Han and Uygur female was high intake of preserved foods（odds ratio=2.729,95% confidence interval =1.762-4.228）and high intake of meat（OR=2.744,95%CI=1.784-4.221）,respectively.However,regularity of menstruation period（OR=0.475,95%CI=0.252-0.893）,high intake of vegetables（OR=0.498,95%CI=0.348-0.712） were protective factor for Han female and late age of menarche（OR=0.676,95%CI=0.536-0.812）,long time of breast feeding（OR=0.496,95%CI=0.269-0.618）,and more parity（OR=0.306,95%CI=0.097-0.965） were protective factor for Uygur female.Conclusion The risk factors of female breast cancer are different between Han and Uygur nationality in Xinjiang area.