鸡贫血病毒感染新城疫免疫雏鸡vNDV攻击后免疫病理学变化

CHANGESOFIMMUNOPATHOLOGYPOSTvNDVCHALLENGEOFCAVINFECTEDCHICKSIMMUNIZEDWITHNDVACCINE

本文对鸡贫血病毒（ＣＡＶ）感染新城疫（ＮＤ）免疫雏鸡经新城疫强毒（ｖＮＤＶ）攻击后，其血清、泪液、气管液、肠液、胆汁的ＩｇＧ、ＩｇＭ、ＩｇＡ含量和ＨＩ抗体滴度；胸腺、法氏囊、脾脏、哈德尔腺、盲肠扁桃体的Ｔ细胞，ＩｇＧ、ＩｇＭ、ＩｇＡ抗体生成细胞数量以及免疫保护情况进行了检测。结果发现，ＣＡＶ感染ＮＤ免疫雏鸡经ｖＮＤＶ攻击后，上述体液的ＩｇＧ、ＩｇＭ、ＩｇＡ含量和血清ＨＩ抗体滴度均明显低于未感染ＣＡＶ的免疫对照雏鸡；胸腺、脾脏和盲肠扁桃体的Ｔ细胞也明显减少；法氏囊、脾脏、盲肠扁桃体、哈德尔腺的ＩｇＧ、ＩｇＭ、ＩｇＡ抗体生成细胞均程度不同地低于相应的对照雏鸡，其中ＩｇＧ生成细胞ＣＡＶ感染雏鸡减少最明显，感染雏鸡的免疫保护率也明显降低。

TheexperimentwasundertakentodetectthecontentofIgG,IgM,IgAandtiterofHIinserum,tear,trachealfluid,intestinalfluidandbile,thenumberofIgG,IgM,andIgAantibodyproducingcellsandTcellinthymus,bursaFabricius,spleen,cecaltonsilandHarderianglandandtheimmuneprotectiveefficacypostvNDVchallengeofCAVinfectedchicksimmunizedwithNDvaccineTheresultsshowedthatafterchallengewithvNDV,thecontentofIgG,IgM,IgAsignificantlydecreasedintheserum,tear,trachealfluid,intestinalfluid,bileofCAVinfectedchicksimmunizedwithNDvaccineincomparisonwiththoseoftheCAVuninfectedcontrolchicks,thetiterofHIofCAVinfectedbirdsimmunizedwithNDvaccinewasalsomarkedlylowerthanthoseofCAVuninfectedcontrolgroupintheserum,thenumberofTlymphocyte,IgG,IgM,IgAantibodyproducingcellsinthementionedaboveimmuneorgansofCAVinfectedbirdsimmunizedwithNDvaccine,toadifferentdegreerespectively,werelessthanthoseofthecontrolchicksTheimmuneprotectiveefficacyofCAVinfectedbirdsimmunizedwithNDvaccinewasmarkedlylowerthanthoseofCAVuninfectedcontrolgroup