61例肺间质纤维化患者临床证候调查分析

Investigation and analysis on TCM syndrome manifestations in 61 patients with pulmonary interstitial fibrosis

目的探讨肺间质纤维化的临床证候信息,并比较肺纤维化虚证证候与肺CT评分、SF-36量表各维度得分的关系。方法对所收集的61例患者应用聚类分析的统计方法,初步总结肺间质纤维化患者的临床证候信息,并应用秩和检验方法比较肺纤维化各虚证证候与肺CT评分、SF-36量表各维度得分的关系。结果聚类分析与经验辨证结果均为肺肾气虚、瘀血内阻是肺纤维化的临床常见证候,肺脾肾虚组、肺肾虚组肺CT评分相对较高,SF-36量表维度中躯体功能得分较低。结论肺肾气虚、瘀血内阻为肺纤维化的临床常见证候,涉及肾虚的证候肺纤维化病变相对较重。

Objective To discuss the clinical information of pulmonary interstitial fibrosis （PIF）, and compare the relationship between the TCM syndrome manifestations of PIF deficient syndrome and lung CT scores and dimensional scores of SF-36 scale. Methods Clustering method was used in 61 cases of PIF and their chnical information were summed up. The TCM syndrome manifestations of PIF deficient syndrome were compared with lung CT scores and dimensional scores of SF-36 scale by applying rank test. Results The results of both clustering analysis and experiences showed that lung-kidney deficiency and internal blood stasis were the common syndrome manifestations of PIF in clinic, lung CT scores were higher in lung-spleen-kidney deficiency group and lung-kidney deficiency group, and the scores of somatic function were lower in dimensionality of SF- 36 scale. Conclusion The common syndrome manifestations of PIF include lung-kidney deficiency and internal blood stasis. The pathological changes of PIF involving kidney deficiency are more serious.