HO-1与HCV的相关性研究

Researching Progress for Correlation between HO-1 and HCV

血红素加氧酶-1（hemeoxygenase-1，HO-1）在肝脏和脾脏高表达，可以被包括某些病毒感染在内的多种因素诱导表达，具有抗氧化、抗炎、抗凋亡等保护作用。丙型肝炎病毒（hepatitisCvirus，HCV）感染可以造成慢型肝炎、肝硬化和肝癌等疾病，对人类健康造成很大威胁。研究发现HO-1通过影响HCV的复制发挥其保护作用，同时HCV也可以反向调控HO-1的表达。尽管HO-1与HCV相互作用的分子机制还不明确，但H0—1与HCV感染相关性研究不断取得重大进展，将为HCV感染的治疗提供一种新方法。

Heme oxygenase-1 （HO-1） is highly expressed in the liver and spleen, can be induced by many factors including certain virus infections. It plays an important protective role in the tissues by its antioxidative, anti-inflammatory, anti-apoptotic functions. The infection of Hepatitis C virus （HCV） can result in chronic hepatitis, cirrhosis, hepatocarcinoma, which throws a great threat to human health. Many studies have discovered that HO-1 plays its beneficial role in the course of HCV infection through interfering viral replication, while HCV also can regulate HO-1 expression conversely. Although the molecular mechanism for HO-1 and HCV interaction is not clear completely so far, the correlative studies about HO-1 and HCV infection have made great progress, which will provide HCV infection a potential therapeutic approach. This text reviewed the correlative studies regarding HO-1 and HCV infection.