ATP敏感性钾通道亚基Kir6．2突变诱发的糖尿病

Research Dvelopment on Diabetes Induced by Kir6. 2 Mutation

Kit6．2是细胞膜和线粒体膜上KATP通道的组成亚基，存在于胰岛、心肌、骨骼肌、脑等组织中。在胰岛β细胞中，Kit6．2亚基是调节胰岛素分泌的重要因子，Kir6．2的突变会导致新生儿糖尿病、婴儿高胰岛素性低血糖症和2型糖尿病等3种糖尿病的发生。文章综述了近年来有关Kir6．2突变导致的多种糖尿病的研究进展。以期对人们了解Kit6．2亚基的功能和科研人员进一步研究糖尿病的治疗有所帮助。

Kit6. 2 is a constituted subunit of KATP in cell membrane and endo-plasmic reticulum membrane, existed in tissues, such as pancreatic islets, cardiac muscle, brain and so on. In pancreatic β cells, Kit6. 2 is a key component of regulating insulin secretion, the mutation of kir6. 2 induces neonatal diabetes mellitus （NDM） , Persistent hyperinsulinemic hypoglycemia of infancy （PHHI） and type2 diabetes （T2DM） . Our review focuses on the research advance of several kinds of diabetes induced by Kir6. 2 mutation, which intends to promote the study of the function of Kir6. 2 and the further research of the diabetes therapy.