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Kringle5蛋白生物学作用及机制

Kringle 5 Protein＇s Biological Activaty and Its Mechanism
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摘要 Kringle5是血浆纤维蛋白溶酶原的第五个饼环区结构域，在体外具有抑制内皮细胞增殖和迁移、在体内具有抑制血管新生和肿瘤生长的生物活性，在实体瘤、糖尿病视网膜病变、风湿性关节炎等疾病的治疗中有广泛的应用前景。 Kringle 5 is the fifth Kringle of plasminogen. The protein inhibits the proliferation and migration of endothelial cells in vitro and it also inhibit angiogenesis and tumor growth in vivo. Kringle 5 has a wide range of applications in solid tumors, diabetic retinopathy, rheumatoid arthritis, etc. In this paper, the biological activity of Kringle 5 and its possible mechanism are reviewed.
作者 陈显久 牛勃 赵荣瑞
机构地区 山西医科大学生物化学与分子生物学教研室 山西医科大学生理学教研室
出处 《医学分子生物学杂志》 CAS CSCD 2010年第4期368-372,共5页 Journal of Medical Molecular Biology
基金 资助项目：山西省科技攻关项目（No.20080321078）
关键词 KRINGLE 5蛋白 血浆纤维蛋白溶酶原 肿瘤血管抑制剂 Kringle 5 protein, plasminogen, inhibitor of angiogenesis
分类号 R345.1 [医药卫生—基础医学]
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参考文献32

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医学分子生物学杂志
2010年 第4期

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