摘要
Kringle5是血浆纤维蛋白溶酶原的第五个饼环区结构域,在体外具有抑制内皮细胞增殖和迁移、在体内具有抑制血管新生和肿瘤生长的生物活性,在实体瘤、糖尿病视网膜病变、风湿性关节炎等疾病的治疗中有广泛的应用前景。
Kringle 5 is the fifth Kringle of plasminogen. The protein inhibits the proliferation and migration of endothelial cells in vitro and it also inhibit angiogenesis and tumor growth in vivo. Kringle 5 has a wide range of applications in solid tumors, diabetic retinopathy, rheumatoid arthritis, etc. In this paper, the biological activity of Kringle 5 and its possible mechanism are reviewed.
出处
《医学分子生物学杂志》
CAS
CSCD
2010年第4期368-372,共5页
Journal of Medical Molecular Biology
基金
资助项目:山西省科技攻关项目(No.20080321078)