初发高血压患者血压昼夜节律变化与尿微量白蛋白的关系

Relationship between day-night rhythm and urinary microalbumin in patients with initial hypertension

目的:探讨初发高血压病患者血压昼夜节律变化与尿微量白蛋白的关系。方法:将186例初发原发性高血压病患者按照24h动态血压检测结果分为A、B两组:A组为杓形组,共71例;B组为非杓形组,共115例,分别检测血清超敏C反应蛋白和尿微量白蛋白水平。结果:B组的的超敏C反应蛋白水平明显高于A组[(6.97±13.17)mg/L与(2.34±1.49)mg/L(P<0.01)],B组的尿微量白蛋白水平明显高于A组[(21.08±3.97)μg/mL与(11.14±3.32)μg/mL,P<0.01](P<0.01)。结论:初发高血压病患者血压昼夜节律变化与炎症反应、尿微量白蛋白关系密切。

Objective：To investigate the relationship between day-night rhythm,serum levels of high sensitive C.reactive protein （hs-CRP）and urinary microalbumin in the initial hypertension.Methods：186 essential hypertensive patients were divided into 2 groups according to the blood pressure-decreasing ratio,group A（dipping group）71 cases,group B（non-dipping group）115 cases.The grade of atheroma and hs-CRP was examined at the same time.Results：The difference of hs-CRP and the grade of urinary microalbumin were significant,group Bgroup A （P0.01）.Conclusion：In 186 essential hypertensive patients,day-night rhythm correlated with inflammation and carotid atherosclerosis.