血压控制水平对2型糖尿病肾病尿蛋白排泄量的影响

The effect of blood pressure on urinary protein excretion in nephropathy type 2 diabetes

目的探讨血压水平对2型糖尿病肾病(DN)24h尿蛋白排泄量(UPE)的影响。方法测定21例经降压治疗并严格控制血糖水平的DN患者在治疗前后的UPE,按治疗后血压的达标程度分成达标组(A组)和未达标组(B组)。结果与治疗前相比,两组治疗后血压和UPE均有不同程度的下降,A组的下降有统计学意义(P<0.05)。与B组比较,A组在治疗后UPE下降有统计学意义(P<0.05)。结论高血压和高血糖对DN的UPE有影响,在血糖控制的同时,严格控制血压对DN的治疗很重要。

Objective To investigate the effect of the levels of blood pressure on 24 h urinary protein excretion（ UPE） in nephropathy type 2 diabetes. Methods UPE was measured in 21 diabetic nephropathy （ DN） patients. Patients was subdivided into two groups （ A and B） according to the levels of blood pressure. UPE was compared between the subgroups. Results The UPE and blood pressure decreased in two groups after treatment. There are significant difference of UPE and blood pressure in group A after treatment （ P 0. 05）. Significant difference of UPE decreased in group A than in group B after treatment（ P 0. 05）. Conclusion The results suggest that hypertension and hyperglycemia have synergic effects on UPE. Ideal blood pressure controlling at DN is important.