气管插管时机对急性重度有机磷中毒治疗效果的影响

Timing of tracheal intubation impact on the therapeutic effect of acute severe organophosphate poisoning patients

目的 探讨气管插管时机对急性重度有机磷中毒（ASOPP）治疗效果的影响.方法 回顾性分析82例急性重度有机磷中毒伴呼吸衰竭患者资料,其中分为及时气管插管组42例,延时气管插管组40例,比较两组患者的抢救效果.结果 及时气管插管组与延时气管插管组比较,呼吸机使用时间、住院时间均显著缩短（P＜0.01）,治愈率显著提高（P＜0.01）,并发症（中间期肌无力综合症、肺部感染、心脏损害等）差异无统计学意义（P＞0.05）.结论 及时气管插管有助于提高重度有机磷农药中毒患者疗效确切,气管插管最佳时机为呼吸衰竭早期.

Objective To evaluate timing of tracheal intubation impact on the therapeutic effect of acute severe organophosphate poisoning（ ASOPP） patients. Methods Retrospectively analyze 82 ASOPP patients with respiratory failure （ RF）. The patients were divided into timely tracheal intubation group（n = 42） and delay tracheal intubation group （n =40） ,and compare the therapeutic effect of these two groups. Results Compared with timely tracheal intubation patients and delay tracheal intubation patients,total time of mechanical ventilation,hospital day decreased significantly （P〈0.01） ,cure rate increased significantly （P〈0.01） ,but complications [intermediate myasthenia syndrome （IMS） .pulmonary infection,cardiac damage and so on] had no significant difference（P〉0.05）. Conclusion It was exact that the therapeutic effect of timely tracheal intubation on rescuing the ASOPP patients, and the best time to tracheal intubation was in RF early period.