冷冻肛肠区病变的研究

Study of cryotherapy on anorectal diseases

目的：探讨冷冻对常见肛肠病的治疗作用。方法：取自西京医院１５年间冷冻治疗肛肠区良性病变７０１８例，恶性病变６３６例，冷冻前后经电镜观察癌细胞变化及应用单克隆技术检测患者Ｔ细胞亚群、Ｂ细胞水平。结果：内痔、混合痔、慢性肛裂的治愈率分别为８３．５％，６６．８％，６２．４％，尖锐湿疣的消除率１００％，早中期直肠癌冷冻能达到临床治愈，５年生存率４１．１％，晚期直肠癌冷冻能减轻症状和延长生命。结论：冷冻治疗是一项安全、有效的方法。

Objective:To investigate the efficacy of cryotherapy on the common anorectal diseases.Methods:All cases in this study came from the anorectal patients(including benign 7018 cases and malignancy 636 cases)in Xijing Hospital,Who were treated with cryotherapy during the past 15 years. All samples of the tumor tissues were observed by electron microscope.The T lymphocyte subsets and B lymphocytes were detected and counted with monoclonal antibody technique before and after the cryotherapy.Results:The cured percentage of internal hemorrhoid,mixed hemorrhoid and chronic fissura ani reached 83.5%,66.8% and 62.4% respectively.The clearance rate of the verruca acuminata was 100%. Those with rectal carcinoma in early or middle state obtained clinical recovery and 5-year-survival rate of them reached 41.1%. Those in advanced stage relieved and their life time prolonged.Conclusion:The cryotherapy is an effective and safe treatment for the anorectal disorders.