摘要
目的探讨不稳定型心绞痛（ＵＡＰ）患者血清白细胞介素－８（ＩＬ－８）的变化及降纤酶（Ｄｆｂ）对其影响。方法用双抗体夹心酶联免疫吸附法对２５例ＵＡＰ患者及２０名健康人ＩＬ－８进行测定，并与２０例Ｄｆｂ治疗者进行比较分析。结果ＵＡＰ患者血清ＩＬ－８含量明显升高，与健康人比较有显著性差异（Ｐ＜００１），血清ＩＬ－８水平下降速度慢于Ｄｆｂ治疗者，恢复正常水平时间较晚。结论ＵＡＰ患者血清ＩＬ－８水平异常增多，其程度与心肌缺血－再灌注损伤有关。Ｄｆｂ治疗对减轻心肌损害程度有益。
Objective To study the effect of Defibrase medicine on
interleukin 8 (IL-8) in unstable angina pectoris (UAP). Methods We detected serum IL-8 (by
two-step sand with ELISA technique) and serum CK-MB in 25 patients with UAS (non-Defibrase
medicine group),20 patients with UAS (Defibrase medicine group),and 20 health persons (control
group). Results The levels of serum IL-8 in UAS patients were significantly higher than that in
health persons ( P <0 01). The decrease rates of serum IL-8 in non-Deffibrase medicine group
were slower than that in Defibrase medicine group. Conclusion The levels of Serum IL-8 are
abnomal and associate with reperfusion injury. Defibrase medicine is helpful to decrease
myocardical damage. [
出处
《中国急救医学》
CAS
CSCD
北大核心
1999年第4期209-210,共2页
Chinese Journal of Critical Care Medicine
关键词
不稳定型
心绞痛
血清
白细胞介素8
降纤酶
Unstable angina pectoris Serum interleukin 8 Defibrase
medicine
