N端脑利钠肽前体在急性心力衰竭诊断和治疗中的应用

Application of Pro-brain Natriuretic Peptide in Diagnosis and Therapy of Acute Heart Failure

目的:探讨N端血浆脑利钠肽前体(NT-proBNP)对急性心力衰竭的诊断和指导治疗价值。方法:用免疫荧光法测60例急性心力衰竭患者(研究组)及60例同期肺部感染的患者(对照组)血浆NT-proBNP浓度、超声心动图测定的左室射血分数(LVEF),比较两组治疗前后血浆NT-proBNP浓度、LVEF的变化。结果:研究组NT-proBNP明显高于对照组(P<0.01),且血浆BNP水平随NYHA分级增高而升高,亚组分析显示心功能Ⅱ级,Ⅲ级和Ⅳ级组间BNP水平均有明显(P<0.01);治疗后1周NT-proBNP较治疗前显著降低(P<0.01)。结论:监测NT-proBNF水平对急性心力衰竭的诊断和治疗具有指导作用。

Objective：To investigate the value of plasma pro-brain natfiuretic peptide （NT-proBNP） in diagnosis and indicator for therapy of acute heart failure （AHF）. Methods： The concentrations of plasma NT-proBNP measured by immune-fluorescence assay and left ventricular ejection fraction （LVEF） detected by eehocardiography in 60 patients with AFH （ research group） and 60 patients with pneumonia （control group） were compared before and after therapy.Results：The concentration of pro-BNP in research group was significantly higher than that in control group （P〈0.01）,the BNP levels were increased with the higher grade in NYHA classification and had a significantly difference in 3 different sub-groups of cardiac function （P〈0.01）.Tbe concentration of BNP in each group was significantly lower after one week treatment （P 〈 0.01 ）. Conclusion：Monitoring pro-BNP level can be used as the indicator for diagnosis and treatment for patients with AHF.