兔心包粘连模型的制作及病理组织学观察

Pathohistological study of Pericardial Adhesion in Rabbit Model

应用日本大白兔，直视下刺破心肌表面，使血积于心包腔内，制作心包粘连模型，而后对其心包进行形态和组织学检查。结果表明：实验组心包粘连、增厚及炎症发生率高、程度重，心包间皮细胞损伤甚至消失，心肌损伤，出现胸腹水。提示心包粘连可能因间皮细胞损伤、纤溶能力下降而致。

In an attempt to simulate pericardial adhesion, a rabbit modelwas made by puncturing myocardium surface in 9 rabbits, causing theblood into their pericardial cavity. After 20 days, the experimentalrabbits and 9 controls ds were available,for post examination. Themodel showed that the incidence of pericardial adhesion increased (P>0.01) and the degree of pericardial adhesion was similar to thoseseen in clinic. This study provide a useful experimental model for re-searches of pericardial adhesion.