新疆多民族族健康人群eNOS基因G894T多态性分析

目的:研究新疆哈萨克族、土尔扈特蒙古族、汉族、维吾尔族健康人群内皮型一氧化氮合成酶(eNOS)基因G894T多态性分布。方法:采用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP)的方法,分别对新疆哈萨克族、维吾尔族、土尔扈特蒙古族、汉族健康人群作eNOS基因G894T多态性检测,分类计数进行统计学处理。结果:新疆哈萨克族、维吾尔族、土尔扈特蒙古族、汉族健康人群eNOS基因GG、GT、TT基因型频率(P>0.005)及G、T等位基因频率(P>0.005)。结论:eNOS基因G894T多态性分布种族之间没有显著性差异,种族内等位基因型频率分布男女间差异无显著性(P>0.05)。

Objective ：To study the eNOS gene related topolymorphism of G894T in Han, Mongolian, Uyger and Hasake nationality. In Xingiang. Method ： To polymerized chain reaction -restriction fragment length palymorphism（PCR- RFLP）in healthy subjects of Han, Mongolian, Uyger and Hasake nationality in Xinjiang. the classified and countered results were processed by statistical analysis. Results：Test results show no significant difference in GG GT TT of eNOS genefrequency （ P 〉 0. 005 ） in healthy subjects of Han, Mongolian, Uyger and Hasake nationality. In Xinjiang, and theallele frequency of G and T（ P 〉 0.005 ）. Conclusion ： There is an ethnic no difference in the distribution of the NOS gene related topolymorphism of G894T,not associated with the gender（P 〉 0.005）.