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多发伤患者血浆中PCT含量及对脓毒症的预测价值 被引量:3

Influence of Plasma PCT Levels on Predictive Value of Multiple Trauma with Sepsis
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摘要 目的监测多发伤患者早期血浆中前降钙素(PCT)的含量,探讨它与多发伤后并发脓毒症之间的关系,评价对多发伤后并发脓毒症的预测价值。方法 50例存在全身炎症综合征的多发伤患者,入住ICU后1h内留取血标本,采用德国Brahms Diagnostica公司生产的LUMItest PCT试剂,应用双抗夹心免疫发光法对血清前降钙素进行半定量检测;根据是否合并感染分为脓毒症组(20例)与非脓毒症组(30例),评价PCT预测多发伤后并发脓毒症的敏感度、特异性。结果 (1)脓毒症组(S组)多发伤患者入ICU时血浆PCT(中位数3.0,范围1.0~4.0)明显高于非脓毒症组(NS组)(中位数1.0,范围1.0~4.0)。(2)PCT对合并脓毒症的多发伤患者诊断的敏感性、特异性、PPV、NPV分别为85.0%(17/20)、80.0%(24/30)、73.9%(17/23)和88.9%(24/27)。结论多发伤患者早期血浆PCT含量明显升高,有并发脓毒症的倾向;PCT可作为多发伤后并发脓毒症的早期预警指标,且其敏感度和特异性较高。 Objective To investigate the serum PCT level in multiple trauma with sepsis and the relationship between PCT and multiple trauma with sepsis in an effort to evaluate the effect of the level on the predictive value in multiple trauma with sepsis.Methods (1)The serum PCT was determined within the first hour after 50 cases of the whole body inflammation syndrome were admitted to ICU.The semi-quantitative detection of the serum procalcitonin concentration was carried out by Double-antibody sandwichimmunoluminometric assay (PCT-Q,BRAHMS Diagnostica,Germany).Sensitivity, specificity and predictive values of procalcitonin in multiple trauma with sepsis were evaluated.(2)Fifty cases were divided into two groups:Sepsis group (S group, 20cases) and non-sepsis group (NS group, 30 cases) according to whether to complicate infection.Results (1)The serum PCT at admission to ICU was significantly higher in S group(media 3.0,range 1.0-4.0),compared with NS group(media 1.0,range 1.0-4.0).(2)Sensitivity,specificity,PPV and NPV to multiple trauma with sepsis were 85.0%(17/20),80.0%(24/30),73.9%(17/23)and88.9% (24/27),respectively.Conclusion The serum PCT level is high early time in multiple trauma with a concurrent sepsis tendency, and the serum PCT can be used as an early warning target of multiple trauma with sepsis, with high sensitivity and specificity.
出处 《中国现代医生》 2010年第22期45-46,57,共3页 China Modern Doctor
关键词 多发伤 脓毒症 前降钙素 双抗夹心免疫发光法检测PCT Multiple trauma Sepsis Procalcitonin PCT-Q
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  • 1姚咏明,盛志勇.脓毒症研究的若干新动态[J].中国危重病急救医学,2000,12(6):323-325. 被引量:68
  • 2金鸿宾.创伤学[M].天津:天津科学技术出版社,2003.230-250.
  • 3Garner JS,Jarwis WR,Emori TG,et al. CDC definitions for nosocomial infections[J]. Am J Infect Control, 1998,16(3) : 128-140.
  • 4医院感染诊断标准(试行)[J].中华医学杂志,2001,81(5):314-320. 被引量:6029
  • 5American College of Chest Physicians/ So City of Critical,Care Medicine Consensus Conference. Definitions for sepsis and multiple organ failure and guidelines for the use of innovative therapies in sepsis[J]. Crit Care Med, 1992,20:864-874.
  • 6Warren HS. Strategies for the treatment of sepsis[J]. N Engl J Med, 1997,336 : 352.
  • 7Wanner GA, Keel M, Steckhoizer U, et al. Relationship between procal-citonin plasma levels and severity of injury,sepsis,organ failure,and mortality in injured patients[J]. Crit Care Med,2000,28 (4) :950-957.
  • 8Oberhoffer M,Vogelsang H,Russw S,et al. Outcome prediction by traditional and new markers of inflammation in patients with sepsis [J]. Celin Chum Lab Med,1999,37(3):363.
  • 9张立天,陆家齐,姚咏明.脓毒症的预警指标及临床意义[J].中国危重病急救医学,2001,13(5):304-306. 被引量:23
  • 10卞建民,王书奎,江滨,戴莲.多种细胞因子监测对严重感染患者的意义[J].中国危重病急救医学,2002,14(6):353-355. 被引量:64

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  • 1姚咏明,盛志勇,林洪远,柴家科.2001年国际脓毒症定义会议关于脓毒症诊断的新标准[J].中国危重病急救医学,2006,18(11):645-645. 被引量:192
  • 2Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17 -producing CIM + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages [ J ]. Nat hnmunol, 2005, 6 (11): 1123-1132.
  • 3Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ ACCP/ATS/SIS international Sepsis Definitions Conference [ J ]. Crit Care Med, 2003, 31 (4) : 1250 - 1256.
  • 4McKenzie BS, Kastelein RA, Cua DJ, et al. Understanding the IL - 23 - IL - 17 immune pathway [ J ]. Trends Immunol, 2006, 27(1): 17 -23.
  • 5Saito K, Wagatsuma T, Toyama H, et al. Sepsis is characterized by the increases in percentages of circulating CIM + CD25 + regula- tory T cells and plasma levels of soluble CD25 [ J ]. Tohoku J Exp Med, 2008, 216(1): 61 -68.
  • 6Neely CJ, Maile R, Wang MJ, et al. Thl7 (IFNγ/ - ILl7 + ) C1M + T cells generated after burn injury may be a novel cellular mechanism for postbum immunosuppression [ J ]. J Trauma, 2011,70(3) : 681 -690.
  • 7Gebhard F, Pfetsch H, Steinbach G, et al. Is interleukin 6 an early marker of injury severity following major trauma in humans [J]. Arch Surg, 2000, 135(3) : 291 -295.
  • 8王一.C-反应蛋白在临床中的应用[J].中外健康文摘,2012,9(3):239-240.
  • 9盛志勇,姚咏明.近年来国内有关创伤后脓毒症研究的一些进展[Z].2002:1-8.
  • 10Domfnguez Comesana E,Ballinas Miranda J R. Procalci-tonin as a marker of intra-abdominal infection [ J ]. CirCir, 2014,82(2) :231-239.

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