期刊文献+

英夫利西联合肠道微生态制剂治疗难治性克罗恩病的临床观察 被引量:2

下载PDF
导出
摘要 目的探讨治疗克罗恩病的有效方法。方法患者静脉注射英夫利西单抗(首次给予5mg/kg,在首次给药后的第2周和第6周及以后每隔8周各给予1次相同剂量)联合口服双歧杆菌四联活菌片(一日3次,一次2片)治疗46周。结果患者经联合治疗6周后,腹痛、腹泻症状明显缓解,全身营养状况改善迅速,46周后症状消失。结论英夫利西联合肠道微生态制剂治疗克罗恩病可有效减轻患者症状。
出处 《中国现代医生》 2010年第22期119-119,共1页 China Modern Doctor
  • 相关文献

参考文献3

二级参考文献46

  • 1高敏,曹倩,罗灵和,吴敏良,胡伟玲,姒健敏.NOD2/CARD15基因多态性与克罗恩病患者相关性研究[J].中华内科杂志,2005,44(3):210-212. 被引量:22
  • 2Carsten Büning,Herbert Lochs.Conventional therapy for Crohn's disease[J].World Journal of Gastroenterology,2006,12(30):4794-4806. 被引量:2
  • 3Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease[J]. Nature, 2001,411 (6837):599-603.
  • 4Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease[J]. Nature, 2001, 411 (6837):603-606.
  • 5Hampe J, Cuthbert A, Croucher PJ, et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations[J]. Lancet, 2001, 357(9272): 1925-1928.
  • 6Kobayashi KS, Chamaillard M, Ogura Y, et al. NOD2-dependent regallation of innate and adaptive immunity in the intestinal tract[J]. Science, 2005, 307(5710):731-734.
  • 7Inoue N, Tamura K, Kinouchi Y, et al. Lack of common NOD2 variants in Japanese patients with Crohn's disease[j]. Gastroenterology, 2002, 123(1):86-91.
  • 8Leong RW, Armuzzi A, Ahmad T, et al. NOD2/CARD15 gene polymnrphisms and Crohn's disease in the Chinese population[J]. Aliment Pharmacol Ther, 2003, 17(12): 1465-1470.
  • 9Arnott ID, Nimmo ER, Drummond HE, et al. NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? [J]. Genes Immun, 2004, 5(5):417-425.
  • 10Sugimura K, Taylor KD, Lin YC, et al. A novel NOD2/CARD 15 haplotype conferring risk for Crohn's disease in Ashkenazi Jews[J]. Am J Hum Genet, 2003, 72(3):509-518.

共引文献14

同被引文献12

引证文献2

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部