苯那普利降低慢性肾炎尿蛋白的临床观察

The effect of benazepril on decreasing urinary protein in patients with chronic glomerulonephritis

目的：了解苯那普利的降低慢性肾小球肾炎尿蛋白的作用。方法；对慢性肾炎病人６４例进行多中心自身对照观察。结果：经苯那普利治疗１２周后，大量蛋白尿组尿蛋白下降４７．０％，小量蛋白尿组尿蛋白下降４７．５％，平均起效时间分别为（５．１±３．２）周和（２．７±２．１）周，同时其中１４例肾病综合征患者的低白蛋白血症也有明显改善。

To investigate the effect of benazepril on proteinuria in patients with chronic glomerulonephritis. Methods: A multi-centered and self-controlled study was performed and 64 patients with chronic glomerulonephritis were included. Results:After 12 weeks of treatment, urinary protein decreased by 47. 0 % and 47. 5 % in heavy proteinuria group (30 cases) and in mild proteinuria group (34 cases), respectively. Significant improvement of hypoalbuminemia was found in 14 patients with nephrotic syndrome. Conclusion: Benazepril can significantly decrease proteinuria in patients with chronic glomerulonephritis.