老年脑血管病急性期患者血清sIL-2R水平的检测及其临床意义

Serum Levels of Soluble Interleukin 2 Receptor in Aged Patients with Acute Cerebrovascular Disease

目的：探讨可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）在老年脑血管病（ＣＶＤ）急性期发生、发展中的作用。方法：采用双抗体夹心ＥＬＩＳＡ方法，对７２例老年ＣＶＤ急性期患者和２８例正常对照组血清ｓＩＬ－２Ｒ进行了测定。结果：与正常对照组相比，老年脑出血组和脑血栓组急性期ｓＩＬ－２Ｒ水平均明显升高（Ｐ＜０．０１）；ｓＩＬ－２Ｒ水平与脑出血量多少无相关性（ｒ＝０．１４２，Ｐ＞０．０５），而与不同出血部位有关；ｓＩＬ－２Ｒ水平随着病情的好转而下降。结论：ｓＩＬ－２Ｒ可作为判断老年ＣＶＤ急性期患者病情变化的指标之一。

Objective: The purpose of this paper was to understand the effects of soluble interleukin 2 recepter (sIL 2R) on the formation and development process of aged patients with acute cerebrovascular disease (CVD). Methods: Levels of sIL 2R in serum were measured in 72 aged patients with acute CVD and 28 normal controls (NC) by ELISA method. Results: The levels of sIL 2R in the serum were significantly increased in cerebral hemorrhage (CH) and cerebral ischemia (CI) group as compared with NC group ( P <0 01). The levels of sIL 2R were different in patients with various hemorrhagic locations, but no correlation ( r=0 142, P >0 05) was found between the level of sIL 2R and the amount of CH. The sIL 2R levels in the serum from aged patients with acute CH and CI were significantly decreased in 4 weeks after treatment. Conclusion: sIL 2R would be one of the important parameters for clinical evaluation in aged patients with acute CVD.