慢性阻塞性肺疾病急性加重期患者血浆白介素10、白介素13浓度与治疗效果的相关性研究

Relationship among the concentration of plasma interleukin-10 and interleukin 13 and patients with acute exacerbated chronic obstructive pulmonary disease and its therapeutic effect-13

目的 探讨COPD急性加重期（AECOPD）患者血浆白介素（IL）-10、IL-13浓度与临床治疗效果之间的关系.方法 36例AECOPD住院治疗患者被纳入研究,用酶联免疫吸附试验检测患者入院时的血浆IL-10和IL-13浓度,对患者的临床表现进行量化评分,根据患者入院时、治疗48h、治疗96 h的临床表现积分结合肺通气功能指标对治疗效果进行评价,分析IL-10、IL-13浓度与治疗效果之间的关系.结果 IL-10浓度与治疗48 h临床表现积分降低值和肺通气功能改善值的相关系数分别为0.85和0.48,与治疗96 h临床表现积分降低值和肺通气功能改善值的相关系数分别为0.64和0.52;IL-13浓度与治疗48 h临床表现积分降低值和肺通气功能改善值的相关系数分别为-0.41和-0.34,与治疗96h临床表现积分降低值的相关系数为-0.36;以上相关系数均具有统计学意义（P＜0.05）.结论 血浆IL-10浓度与AECOPD治疗效果呈正相关而IL-13浓度与治疗效果呈负相关.

Objective To investigate the relationship among the concentration of plasma interleukin （IL）-10 and plasma IL-13 and the clinical therapeutic effect in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）.Methods Thirty-six AECOPD inpatients were enrolled in this study.Blood samples of the subjects were collected as soon as hospitalization, and plasma IL-10 and IL-13concentrations were analyzed by enzyme-linked immunosorbent assay.The clinical manifestations of subjects were quantified by a special designed score standard, and were evaluated at the time points of hospitalization, 48 hours treatment and 96 hours treatment.The therapeutic effect was evaluated by clinical manifestations score combined with pulmonary ventilation functional parameter.Eventually, the correlation among the concentration of IL-10 concentration and IL-13 and the clinical therapeutic effect were analyzed.Results The correlation coefficients between clinical manifestations score decrease and pulmonary ventilation function improvement with plasma IL-10 concentration after 48 hours treatment were 0.85 and 0.48 respectively,then, 0.64 and 0.52 after 96 hours treatment.The correlation coefficients between clinical manifestations score decrease and pulmonary ventilation function improvement with plasma IL-13 concentration after 48hours treatment were -0.41 and -0.34, after 96 hours treatment , correlation coefficients between clinical manifestations score decrease with plasma IL-13 concentration was -0.36.All of the above correlation coefficients were statistically significant.Conclusion Plasma IL-10 concentration was positively, whereas, IL-13 concentration was negatively correlated with the therapeutic effect in AECOPD patients.