吡格列酮联合厄贝沙坦对原发性高血压患者左心室肥厚及血清脑钠肽的影响

Effect of pioglitazone unietd irbesartan on hypertension with left ventricular hypertrophy and brain natriuretic peptide

目的 探讨吡格列酮对原发性高血压患者左心室肥厚及脑钠肽的影响.方法 原发性高血压伴左心室肥厚患者80例完全随机分成2组,各40例.常规治疗组给予厄贝沙坦（150 mg/d）,吡格列酮组给予厄贝沙坦（150 mg/d）＋吡格列酮（15 mg/d）,均治疗6个月.比较2组治疗前后左心室质量指数（LV MI）、血清脑钠肽浓度的变化.结果 治疗后2组患者LVMI、血清脑钠肽浓度均下降（P＜0.05）,2组治疗后比较,吡格列酮组LVMI、血清脑钠肽浓度下降为[（126.2±10.4）g/m2、（113.6±42.9）ng/L,较常规治疗组[分别为（135.5±11.2）g/m2、（138.8±45.8）ng/L]明显（P＜0.05）.结论 吡格列酮能逆转高血压病患者的左心室肥厚,并降低血清脑钠肽浓度.

Objective To explore the effect of Pioglitazone on hypertension with left ventricular hypertrophy and brain natriuretic peptide. Methods Eighty cases of hypertension patients were selected and randomly divided into pioglitazone group and the conventional treatment group. Conventional treatment group were treated with irbesartan （150 mg/d） ; pioglitazone group were treated with irbesartan （ 150 mg/d） and pioglitazone （ 15 mg/d）. Both treatment lasted for 6 months. The changes of the levels of left ventricular mass index （LVMI） , serum brain natriuretic peptide（BNP） were compared between two groups before and after treatment. Results The levels of LVMI,serum BNP decreased after treatment in the pioglitazone group and the conventional treatment group. There were significant differences before and after treatment （P 〈 0. 05）. After treatment, the levels of LVMI, serum BNP decreased significantly in the pioglitazone group（ P 〈 0.05）. Conclusion Pioglitazone can reverse left ventricular hypertrophy and reduce serum concentration of brain natriuretic peptide.