不同剂量阿托伐他汀对急性冠状动脉综合征患者血浆P选择素的影响

Effects of atorvastatin on serumsoluble P-selectin level in acute coronary syndrome

目的 探讨不同剂量的阿托伐他汀对急性冠状动脉综合征患者血浆中P选择素的影响.方法 将120例急性冠状动脉综合征患者完全随机分为2组.对照组（40例）予常规治疗,阿托伐他汀治疗组（80例）在常规治疗的基础上加用阿托伐他汀口服,1次/d.同时根据阿托伐他汀的用量,将阿托伐他汀组分为阿托伐他汀10 mg组及阿托伐他汀40mg组.在治疗前及治疗1周后分别测量血浆P选择素水平.结果 3组治疗前P选择素水平差异无统计学意义（P＞0.05）.治疗后3组P选择素水平均下降,与治疗前比较,差异有统计学意义[对照组、阿托伐他汀10 mg组及阿托伐他汀40 mg组分别为（119.2±78.9）μg/L,（88.8±63.9）μg/L、（56.4±53.1）μg/L,P＜0.05],阿托伐他汀治疗组降幅大于对照组,其中阿托伐他汀40 mg组下降幅度更明显,与10 mg组比较,差异有统计学意义（P＜0.05）.结论 阿托伐他汀可使冠心病血浆中P选择素明显下降,这可能与其能抑制白细胞和血小板与内皮的黏附聚集有关;早期予强化高剂量的阿托伐他汀治疗可能获得更大的益处.

Objective To study the effects of Atorvastatin on serumsoluble P-selectin level in Acute Coronary Syndrome. Methods One huanred and twenty Acute coronary syndrome were randomly divided into three groups including atorvastatin in high dosage group（40 mg, n = 40） ,atorvastatin in low dosage group（ 10 mg, n =40） and control group（n =40）. Patients with atorvastatin were taked orally per day for one weeks. Before and after treated one week, the concentrations of P-selectin were measured by ELISA. Results Compared with before routine treatment, the level of P-selectin has a significantly decreese. Compared with before atorvastatin treatment, the level of P-selectin has a significantly decrease after one week. Compared with routine treatment group, atorvastatin has a significally decrease the level of P-selectin in one week and the level of P-selectin of atorvastatin in high dosage group has more significantly decreese than low dosage group （P 〈0. 05）. Conclusions Atorvastatin can decrease the level of P-selectin in acute coronary syndrome.