醛固酮合酶基因-344C/T多态性与心房颤动关系的研究

Association between aldosterone synthase gene polymorphism and atrial fibrillation in patients with chronic heart failure

目的:探讨慢性心力衰竭(CHF)患者醛固酮合酶(CYP11B2)基因-344C/T多态性与心房颤动的关系。方法:136例CHF患者被分为心房颤动组(59例)和窦性心律组(77例)。应用聚合酶链式反应-限制性片段长度多态性(PCR-RELP)分析技术对136例慢性心力衰竭的CYP11B2基因-344C/T多态性进行分析。结果:与窦性心律的心衰患者比较,CT+CC基因型更多见于合并房颤的心衰患者[(31+7)%∶(51±8)%,x2=6.29,P=0.012]。结论:慢性心力衰竭人群CYP11B2基因-344C/T多态性与心房颤动有关。

Objective： To investigate the possible association between aldosterone synthase （CYPllB2） -344G/T polymorphism and atrial fibrillation in patients with chronic heat failure from a population of Chinese Han nationality. Methods： The restrict fragment length polymormisms （RFLP） at-344 site of CYP11B2 gene were studied using polymerase chain reaction （PCR） technique in 136 subjects with chronic heart failure. Results： The frequency of TC＋CC genotypes were significantly higher in chronic heart failure patients who existed atrial fibrillation compared with those of sinus rhythm group [- （51＋ 8）% vs. （31 ＋ 7）%, x^2= 6.29, P= 0. 012]. Conclusion： It is considered that there is a significant association between aldosterone synthase gene-344C/T polymorphism and atrial fibrillation in Chinese patients with chronic heart failure.