摘要
目的 探讨转录因子Snail及黏附分子E-cadherin在直肠癌中的表达及意义.方法 采用免疫组化SABC法检测101例直肠癌组织中Snail、E-cadherin的表达,分析二者在不同临床病理分期与分化程度的直肠癌中的表达及其与预后的关系.结果 免疫组化检测结果显示直肠癌组织中Snail的阳性表达率为78.2%（79/101）,直肠癌组织中E-cadherin的阳性表达缺失率为62.4%（63/1 01）,Snail与E-cadherin的表达呈显著负相关.Snail、E-cadherin的表达与直肠癌的Dukes分期及淋巴结转移有关（P＜0.05）.结论 Snail蛋白的高表达和E-cadherin蛋白的低表达可能是直肠癌侵袭转移的重要生物学标志.
Objective To investigate the expression of E-cadherin and Snail proteins in rectal cancer and their significance. Methods The expression of Snail and E-cadherin proteins was detected using immunohistochemical SABC method in 101 cases of rectal cancer tissues. Results The positive rate of Snail in rectal cancer was 78.2% （79/101）. The negative expression rate of E-cadherin in rectal cancer was 62.4% （63/101）. The expression of Snail and E-cadherin were significantly related with the lymph node metastasis and Dukes＇ stage of rectal cancer （P ＜ 0.05）. Conclusion The overexpression of Snail and the decreased expression of E-cadherin might be important biological markers for malignant transformation, invasion and metastasis of rectal carcinoma.
出处
《国际外科学杂志》
2010年第8期514-519,F0003,共7页
International Journal of Surgery
